Michael F. Czarniecki: search on Z-Library

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1

The Gif system as a tool in medicinal chemistry: The oxidation of Sch 57726 under GoAggIII conditions

Darío Doller, Samuel Chackalamannil, Andrew Stamford, Brian McKittrick, Michael Czarniecki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 368 KB

english, 1997

2

Synthesis and phosphodiesterase activity of carboxylic acid mimetics of cyclic guanosine 3',5'-monophosphate

Tulshian, Deen, Czarniecki, Michael, Doll, Ronald J., Ahn, Ho Sam

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 1.88 MB

english, 1993

3

ChemInform Abstract: Guanine Hydrolysis to Substituted Imidazoles under Basic Conditions.

Dinesh Gala, Mohindar S. Puar, Michael Czarniecki, Pradip R. Das, Max Kugelman, James J. Kaminski

Journal:

Year:

2000

File:

PDF, 28 KB

2000

4

Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1) Antagonists as Novel Antithrombotic Agents

Chackalamannil, Samuel, Xia, Yan, Greenlee, William J., Clasby, Martin, Doller, Darìo, Tsai, Hsingan, Asberom, Theodros, Czarniecki, Michael, Ahn, Ho-Sam, Boykow, George, Foster, Carolyn, Agans-Fantuz

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 88 KB

english, 2005

5

Carbon-13 nuclear magnetic resonance of ganglioside sugars. Spin-lattice relaxation probes for structure and microdynamics of cell surface carbohydrates

Czarniecki, Michael F., Thornton, Edward R.

Journal:

Journal of the American Chemical Society

Year:

1977

Language:

english

File:

PDF, 500 KB

english, 1977

6

Guanine hydrolysis under basic conditions to substituted imidazoles

Dinesh Gala, Mohindar S. Puar, Michael Czarniecki, Pradip R. Das, Max Kugelman, James J. Kaminski

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 190 KB

english, 2000

7

Synthesis and evaluation of potent and selective c-GMP phosphodiesterase inhibitors

Ginny Dai Ho, Silverman Lisa, Ana Bercovici, Chester Puchalski, Deen Tulshian, Yan Xia, Michael Czarniecki, Michael Green, Renee Cleven, Hongtao Zhang, Ahmad Fawzi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 260 KB

english, 1999

8

Discovery of Novel Chemotypes to a G-Protein-Coupled Receptor through Ligand-Steered Homology Modeling and Structure-Based Virtual Screening

Cavasotto, Claudio N., Orry, Andrew J. W., Murgolo, Nicholas J., Czarniecki, Michael F., Kocsi, Sue Ann, Hawes, Brian E., O’Neill, Kim A., Hine, Heather, Burton, Marybeth S., Voigt, Johannes H., Abagy

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 904 KB

english, 2008

9

Small peptide inhibitors of smooth muscle myosin light chain kinase

Gaeta, Federico C. A., Lehman de Gaeta, Laura S., Kogan, Timothy P., Or, Yat Sun, Foster, Carolyn, Czarniecki, Michael

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.29 MB

english, 1990

10

Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: Part 2

Stephanie Brumfield, Julius J. Matasi, Deen Tulshian, Michael Czarniecki, William Greenlee, Charles Garlisi, Hongchen Qiu, Kristine Devito, Shu-Cheng Chen, Yongliang Sun, Rosalia Bertorelli, Justin An

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 470 KB

english, 2011

11

Discovery of melanin-concentrating hormone receptor R1 antagonists using high-throughput synthesis

Jing Su, Brian A. McKittrick, Haiqun Tang, Michael Czarniecki, William J. Greenlee, Brian E. Hawes, Kim O’Neill

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 166 KB

english, 2005

12

Design and synthesis of phosphinic acids that triply inhibit endothelin converting enzyme, angiotensin converting enzyme and neutral endopeptidase 24.11

Brian A. McKittrick, Andrew W. Stamford, Xiaoyu Weng, Ke Ma, Samuel Chackalamannil, Michael Czarniecki, ReneéM. Cleven, Ahmad B. Fawzi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 304 KB

english, 1996

13

Carbon-13 spin lattice relaxation in the neuraminic acids. Evidence for an unusual intramolecular hydrogen bonding network

Czarniecki, Michael F., Thornton, Edward R.

Journal:

Journal of the American Chemical Society

Year:

1976

Language:

english

File:

PDF, 389 KB

english, 1976

14

Iminopyrimidinones: A novel pharmacophore for the development of orally active renin inhibitors

McKittrick, Brian A., Caldwell, John P., Bara, Thomas, Boykow, George, Chintala, Madhu, Clader, John, Czarniecki, Michael, Courneya, Brandy, Duffy, Ruth, Fleming, Linda, Giessert, Rachel, Greenlee, Wi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 723 KB

english, 2015

15

Synthesis and structure–activity relationships of new disubstituted phenyl-containing 3,4-diamino-3-cyclobutene-1,2-diones as CXCR2 receptor antagonists

Gaifa Lai, J. Robert Merritt, Zhenmin He, Daming Feng, Jianhua Chao, Michael F. Czarniecki, Laura L. Rokosz, Tara M. Stauffer, Diane Rindgen, Arthur G. Taveras

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 152 KB

english, 2008

16

Potent, low molecular weight thrombin receptor antagonists

Samuel Chackalamannil, Darı́o Doller, Keith Eagen, Michael Czarniecki, Ho-Sam Ahn, Carolyn J. Foster, George Boykow

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 89 KB

english, 2001

17

Small Molecule Modulators of Toll-like Receptors

Czarniecki, Michael

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 398 KB

english, 2008

18

Synthesis of highly functionalized trans-alkene isosteres of dipeptides

Lehman de Gaeta, L. S., Czarniecki, Michael, Spaltenstein, Andreas

Journal:

Journal of Organic Chemistry

Year:

1989

Language:

english

File:

PDF, 271 KB

english, 1989

19

Use of multiparmetric MRI and Fusion-Guided Biopsies to Properly Select and Follow African-American Men on Active Surveillance

Bloom, Jonathan B., Lebastchi, Amir H., Gold, Samuel A., Hale, Graham R., Sanford, Thomas, Mehralivand, Sherif, Ahdoot, Michael, Rayn, Kareem N., Czarniecki, Marcin, Smith, Clayton, Valera, Vladimir,

Journal:

BJU International

Year:

2019

Language:

english

File:

PDF, 659 KB

english, 2019

20

Total Synthesis of Griseolic Acid

Tulshian, Deen B., Czarniecki, Michael

Journal:

Journal of the American Chemical Society

Year:

1995

Language:

english

File:

PDF, 181 KB

english, 1995

21

An efficient synthesis of Wiedendiol-A from (+)-sclareolide

Samuel Chackalamannil, Yuguang Wang, Yan Xia, Michael Czarniecki

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 164 KB

english, 1995

22

Corrigendum to “Discovery and SAR of cyclic isothioureas as novel NPY Y1 receptor antagonists” [Bioorg. Med. Chem. Lett. 19 (2009) 6801]

Zhong-Yue Sun, Zhaoning Zhu, Yuanzan Ye, Brian McKittrick, Michael Czarniecki, William Greenlee, Deborra Mullins, Mario Guzzi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 140 KB

english, 2010

23

Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists

Ho-Sam Ahn, Leyla Arik, George Boykow, Duane A. Burnett, Mary Ann Caplen, Michael Czarniecki, Martin S. Domalski, Carolyn Foster, Mahua Manna, Andrew W. Stamford, Yusheng Wu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 262 KB

english, 1999

24

Potentiale und Hindernisse von Crowdsourcing für Unternehmensentwicklung und Geschäftsmodellinnovation – Ein methodischer Ansatz zur Transformation von Organisationen; Crowdsourcing for Business Development and Business Model Innovation – A methodical approach for organizational transformation;

Christ, Oliver, Czarniecki, Michael, Scherer, Lukas, Blohm, Ivo

Journal:

HMD Praxis der Wirtschaftsinformatik

Year:

2017

Language:

german

File:

PDF, 666 KB

german, 2017

25

Photochemical probes for model membrane structures

Czarniecki, Michael F., Breslow, Ronald

Journal:

Journal of the American Chemical Society

Year:

1979

Language:

english

File:

PDF, 300 KB

english, 1979

26

Very Fast acylation of .beta.-cyclodextrin by bound p-nitrophenyl ferrocinnamate

Czarniecki, Michael F., Breslow, Ronald

Journal:

Journal of the American Chemical Society

Year:

1978

Language:

english

File:

PDF, 269 KB

english, 1978

27

Synthesis of C3 Heteroatom-Substituted Azetidinones That Display Potent Cholesterol Absorption Inhibitory Activity

McKittrick, Brian A., Ma, Ke, Huie, Keith, Yumibe, Nathan, Davis, Harry, Clader, John W., Czarniecki, Michael, McPhail, Andrew T.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 185 KB

english, 1998

28

ChemInform Abstract: Design, Synthesis, and Structure—Activity Relationship Studies of Himbacine Derived Muscarinic Receptor Antagonists.

Dario Doller, Samuel Chackalamannil, Michael Czarniecki, Robert McQuade, Vilma Ruperto

Journal:

Year:

1999

File:

PDF, 32 KB

1999

29

Cyclic Hydroxyamidines as Amide Isosteres: Discovery of Oxadiazolines and Oxadiazines as Potent and Highly Efficacious γ-Secretase Modulators in Vivo

Sun, Zhong-Yue, Asberom, Theodros, Bara, Thomas, Bennett, Chad, Burnett, Duane, Chu, Inhou, Clader, John, Cohen-Williams, Mary, Cole, David, Czarniecki, Michael, Durkin, James, Gallo, Gioconda, Greenl

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.46 MB

english, 2012

30

Discovery and synthesis of a novel series of quinoline-based thrombin receptor (PAR-1) antagonists

Martin C. Clasby, Samuel Chackalamannil, Michael Czarniecki, Dario Doller, Keith Eagen, William J. Greenlee, Yan Lin, Hsingan Tsai, Yan Xia, Ho-Sam Ahn, Jacqueline Agans-Fantuzzi, George Boykow, Madhu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 156 KB

english, 2006

31

Potent Tetracyclic Guanine Inhibitors of PDE1 and PDE5 Cyclic Guanosine Monophosphate Phosphodiesterases with Oral Antihypertensive Activity

Ahn, Ho-Sam, Bercovici, Ana, Boykow, George, Bronnenkant, Alan, Chackalamannil, Samuel, Chow, Jason, Cleven, Renee, Cook, John, Czarniecki, Michael, Domalski, Carol

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 418 KB

english, 1997

32

Stereoselective synthesis and biological activity of cis azetidinones as cholesterol absorption inhibitors

Brian A. McKittrick, Ke Ma, Sundeep Dugar, John W. Clader, Harry Davis Jr., Michael Czarniecki, Andrew T. McPhail

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 223 KB

english, 1996

33

Highly potent and selective inhibitors of endothelin converting enzyme

Samuel Chackalamannil, Shin Chung, Andrew W. Stamford, Brian A. McKittrick, Yuguang Wang, Hsingan Tsai, Reneé Cleven, Ahmad Fawzi, Michael Czarniecki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 179 KB

english, 1996

34

Design and discovery of 1,3-benzodiazepines as novel dopamine antagonists

Zhaoning Zhu, Zhong-Yue Sun, Yuanzan Ye, Brian McKittrick, William Greenlee, Michael Czarniecki, Ahmad Fawzi, Hongtao Zhang, Jean E. Lachowicz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.34 MB

english, 2009

35

Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors

Wang, Yu-Sen, Strickland, Corey, Voigt, Johannes H., Kennedy, Matthew E., Beyer, Brian M., Senior, Mary M., Smith, Elizabeth M., Nechuta, Terry L., Madison, Vincent S., Czarniecki, Michael, McKittrick

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.66 MB

english, 2010

36

Metabolism-Based Identification of a Potent Thrombin Receptor Antagonist

Clasby, Martin C., Chackalamannil, Samuel, Czarniecki, Michael, Doller, Dario, Eagen, Keith, Greenlee, William, Kao, Grace, Lin, Yan, Tsai, Hsingan, Xia, Yan, Ahn, Ho-Sam, Agans-Fantuzzi, Jacqueline,

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 170 KB

english, 2007

37

Discovery and SAR of cyclic isothioureas as novel NPY Y1 receptor antagonists

Zhong-Yue Sun, Zhaoning Zhu, Yuanzan Ye, Brian McKittrick, Michael Czarniecki, William Greenlee, Deborra Mullins, Mario Guzzi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 569 KB

english, 2009

38

Himbacine derived thrombin receptor antagonists: Discovery of a new tricyclic core

Martin C. Clasby, Samuel Chackalamannil, Michael Czarniecki, Darío Doller, Keith Eagen, William J. Greenlee, Yan Lin, Jayaram R. Tagat, Hsingan Tsai, Yan Xia, Ho-Sam Ahn, Jacqueline Agans-Fantuzzi, Ge

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 251 KB

english, 2007

39

Dihydrodithioisocoumarin: Novel electrophilic reaction of carbon disulfide with phenethyl alcohol derivatives

Michael Czarniecki, Robert Q. Kluttz

Journal:

Tetrahedron Letters

Year:

1979

Language:

english

File:

PDF, 135 KB

english, 1979

40

13C NMR chemical shift titration of metal ion-carbohydrate complexes. An unexpected dichotomy for Ca+2 binding between anomeric derivatives of N-Acetylneuraminic acid (1)

Michael F. Czarniecki, Edward R. Thornton

Journal:

Biochemical and Biophysical Research Communications

Year:

1977

Language:

english

File:

PDF, 317 KB

english, 1977

41

Substituted 1,3,5-triazines as cholesteryl ester transfer protein inhibitors

Yan Xia, Bita Mirzai, Samuel Chackalamannil, Michael Czarniecki, Suke Wang, Anthony Clemmons, Ho-Sam Ahn, George C. Boykow

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 245 KB

english, 1996

42

Improved acylation rates within cyclodextrin complexes from flexible capping of the cyclodextrin and from adjustment of the substrate geometry

Breslow, Ronald, Czarniecki, Michael F., Emert, Jack, Hamaguchi, Hiroshi

Journal:

Journal of the American Chemical Society

Year:

1980

Language:

english

File:

PDF, 1.19 MB

english, 1980

43

ChemInform Abstract: CARBON-13 SPIN LATTICE RELAXATION IN THE NEURAMINIC ACIDS. EVIDENCE FOR AN UNUSUAL INTRAMOLECULAR HYDROGEN BONDING NETWORK

CZARNIECKI, MICHAEL F., THORNTON, EDWARD R.

Journal:

Chemischer Informationsdienst

Year:

1976

File:

PDF, 100 KB

1976

44

[Annual Reports in Medicinal Chemistry] Volume 31 || Chapter 7. Inhibitors of Types I and V Phosphodiesterase: Elevation of cGMP as a Therapeutic Strategy

Czarniecki, Michael

Year:

1996

Language:

english

File:

PDF, 589 KB

english, 1996

45

Synthesis and Evaluation of Polycyclic Pyrazolo[3,4- d ]pyrimidines as PDE1 and PDE5 cGMP Phosphodiesterase Inhibitors

Xia, Yan, Chackalamannil, Samuel, Czarniecki, Michael, Tsai, Hsingan, Vaccaro, Henry, Cleven, Renee, Cook, John, Fawzi, Ahmad, Watkins, Robert, Zhang, Hongtao

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 313 KB

english, 1997

46

Inhibitors of PDE1 and PDE5 cGMP phosphodiesterases: patents and therapeutic potential

Sybertz, Edmund, Czarniecki, Michael

Journal:

Expert Opinion on Therapeutic Patents

Year:

1997

Language:

english

File:

PDF, 142 KB

english, 1997

47

Himbacine derived thrombin receptor (PAR-1) antagonists: Structure–activity relationship of the lactone ring

Yan Xia, Samuel Chackalamannil, Tze-Ming Chan, Michael Czarniecki, Darío Doller, Keith Eagen, William J. Greenlee, Hsingan Tsai, Yuguang Wang, Ho-Sam Ahn, George C. Boykow, Andrew T. McPhail

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 131 KB

english, 2006

48

Design, synthesis, and structure-activity relationship studies of himbacine derived muscarinic receptor antagonists

Darío Doller, Samuel Chackalamannil, Michael Czarniecki, Robert McQuade, Vilma Ruperto

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 307 KB

english, 1999

49

Ultrastructural analysis of the anti-chlamydial activity of recombinant murine interferon-γ

Luis M. de la Maza, Michael J. Plunkett, Elaine J. Carlson, Ellena M. Peterson, Christine W. Czarniecki

Journal:

Experimental and Molecular Pathology

Year:

1987

Language:

english

File:

PDF, 8.77 MB

english, 1987

50

Carbon-13 nuclear magnetic resonance spin-lattice relaxation in the N-acylneuraminic acids. Probes for internal dynamics and conformational analysis

Czarniecki, Michael F., Thornton, Edward R.

Journal:

Journal of the American Chemical Society

Year:

1977

Language:

english

File:

PDF, 953 KB

english, 1977

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